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Managing director
1968 - 1975: Studies of medicine and research postgraduate studies of molecular genetics and virology, Humboldt University Berlin
since 1975: Assistant physician at Charité Medical School, Berlin
1976: M.D. Thesis, Humboldt University Berlin
1976 - 1977: Postdoctoral fellow, Dept. of Microbiology, Institute of General Genetics, Moscow
1981: Habilitation in Virology and Molecular Genetics, Humboldt University, Berlin
1982 - 1983: Research fellow, Dept. of Microbiology, University of Basel Biocenter, Switzerland
1986 - 1987: Research fellow, Dept. of Molecular Biology & Genetics, Johns Hopkins University Medical School, Baltimore, MD
since 1989: Full professor of virology and director of the Institute of Virology, Charité Medical School, Berlin
since 2002: additional membership in the Faculty of Mathematics and Natural Sciences, Humboldt University, Berlin
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Member of scientific advisory boards
– Society for Virology
– Paul Ehrlich Society for Chemotherapy
– Paul Ehrlich Institute (German Federal Institute for Sera and Vaccines), Langen near Frankfurt
– Institute of Biotechnology/European Biotechnology Center of Excellence, Vilnius, Lithuania
– International Society for Hantaviruses
– Biotechnology Park, Luckenwalde, State of Brandenburg
– Competence center for "Highly infectious, life-threatening diseases", State of Berlin
Scientific interests
• Molecular epidemiology, evolution, cell biology and pathogenesis of infections by emerging viruses including the development of diagnostic tests, vaccines and virus inhibitors (hantaviruses)
• Mechanisms of the reactivation and pathogenesis of virus infections in humans and therapeutic approaches to influence these processes (human cytomegalovirus, hepatitis B virus)
• Molecular recognition by DNA-interacting enzymes (restriction endonucleases, DNA methyltransferases) and their use in molecular diagnostics (transcriptome analysis)
Publications
Klempa B, Schmidt HA, Ulrich R, Kaluz S, Labuda M, Meisel H, Hjelle B, Krüger DH:
Genetic interaction between distinct Dobrava hantavirus subtypes in Apodemus agrarius and A. flavicollis in nature.
J. Virol. 77 (2003) 804-809
Klempa B, Schütt M, Auste B, Labuda M, Ulrich R, Meisel H, Krüger DH:
First molecular identification of human Dobrava virus infection in Central Europe.
J. Clin. Microbiol. 42 (2004) 1322-1325
Kraus AA, Raftery MJ, Giese T, Ulrich R, Zawatzky R, Hippenstiel S, Suttorp N, Krüger DH, Schönrich G:
Differential antiviral response of endothelial cells after infection with pathogenic and nonpathogenic hantaviruses.
J. Virol. 78 (2004) 6143-6150
Matsumura H, Reich S, Ito A, Saitoh H, Kamoun S, Winter P, Kahl G, Reuter M, Krüger DH, Terauchi R:
Gene expression analysis of plant host-pathogen interactions by SuperSAGE.
Proc. Natl. Acad. Sci. USA 100 (2003) 15718-23
Meisel A, Bickle TA, Krüger DH, Schroeder C:
Type III restriction enzymes need two inversely oriented recognition sites for DNA cleavage.
Nature (Lond.) 355 (1992) 467-469
Mücke M, Grelle G, Behlke J, Kraft R, Krüger DH, Reuter M:
EcoRII: a restriction enzyme evolving recombination functions?
EMBO J. 21 (2002) 5262-5268
Preikschat P, Günther S, Reinhold S, Will H, Budde K, Neumeyer HH, Krüger DH, Meisel H:
Complex HBV populations with mutations in core promoter, C gene, and pre-S region are associated with development of cirrhosis in long-term renal transplant recipients.
Hepatology 35 (2002) 466-477
Prösch S, Heine AK, Volk HD, Krüger DH:
CCAAT/enhancer-binding proteins a and ß negatively influence the capacity of tumor necrosis factor a to upregulate the human cytomegalovirus IE1/2 enhancer/promoter by nuclear factor kB during monocyte differentiation.
J. Biol. Chem. 276 (2001) 40712-40720
Reich S, Gössl I, Reuter M, Rabe JP, Krüger DH:
Scanning force microscopy of DNA translocation by the Type III restriction enzyme EcoP15I.
J. Molec. Biol. 341 (2004) 337-343
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Prof
Dr. Detlev Krüger
